Contact information
Chen-Yi Wang
Senior Research Associate
My research interests are focused on chromatin biology and epigenetics. I began my research career as a wet-lab scientist specializing in molecular and cellular biology, with a particular emphasis on next-generation sequencing (NGS)-related experiments and analyses. In order to gain more practical experience with NGS data analyses and bioinformatics, I pursued additional training in CGAT (Computational Genomics Analysis and Training program) upon joining Prof Oppermann's group at the Botnar Research Centre in 2017.
As an experimental and computational biologist, I have applied several NGS analyses, including targeted DNA sequencing, RNA sequencing at both bulk and single-cell levels, and multi-omics integrated analysis, to deepen our understanding of the tumour patho-mechanism, as well as to discover potential targets and pathways for treatments and drug development.
Key publications
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Flickin’ the ubiquitin switch
Journal article
Wright DE. et al, (2011), Epigenetics, 6, 1165 - 1175
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Beating the odds: BETs in disease.
Journal article
Wang C-Y. and Filippakopoulos P., (2015), Trends biochem sci, 40, 468 - 479
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The C-Terminus of Histone H2B Is Involved in Chromatin Compaction Specifically at Telomeres, Independently of Its Monoubiquitylation at Lysine 123
Journal article
Wang C-Y. et al, (2011), Plos one, 6, e22209 - e22209
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Depleting Components of the THO Complex Causes Increased Telomere Length by Reducing the Expression of the Telomere-Associated Protein Rif1p
Journal article
Yu T-Y. et al, (2012), Plos one, 7, e33498 - e33498
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The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription
Journal article
Bonnet J. et al, (2014), Genes & development, 28, 1999 - 2012
Recent publications
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A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding
Preprint
Wang C. et al, (2024)
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Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.
Journal article
Savitsky P. et al, (2016), Cell rep, 17, 2724 - 2737
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Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
Journal article
Picaud S. et al, (2016), Sci adv, 2
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Beating the odds: BETs in disease.
Journal article
Wang C-Y. and Filippakopoulos P., (2015), Trends biochem sci, 40, 468 - 479