Chen group | Human Immunology in Inflammation

liye.chen@ndorms.ox.ac.uk

Core research themes

Tissue-Resident Memory T Cells in health and disease
Role of Myeloid Cells in inflammation and resolution
Developing High-Throughput CRISPR Screens for primary immune cells

Our team

Liye Chen

Career Development Fellow - Arthritis UK
Miaomiao Qiao

Postdoctoral Research Associate in Genomic Screening

Collaborators

Prof. Paul Bowness, University of Oxford

Prof. Christopher Buckley, University of Oxford

Prof. Laura Coates, University of Oxford

Prof. Sarah Snelling, University of Oxford

Prof. Kim Midwood, University of Oxford

Prof. Richard Williams, University of Oxford

Prof. Antoni Chan, University of Reading

Prof. Nicola Ternette, University of Dundee

Prof. Hai Fang, Shanghai Jiao Tong University School of Medicine

Visiting Postdoc

Dr Lili Jiang

Our Institutes

Botnar Research Centre

Kennedy Institute of Rheumatology

Our publications

Read our research

All publications

computational medicine framework integrating multi-omics, systems biology, and artificial neural networks for Alzheimer's disease therapeutic discovery.

Yang Y. et al, (2025), Acta Pharm Sin B, 15, 4411 - 4426

CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue.

Liu F. et al, (2025), Ann Rheum Dis, 84, 1151 - 1163

HLA-B27 and spondyloarthritis: at the crossroads of innate and adaptive immunity.

Navid F. et al, (2025), Nat Rev Rheumatol, 21, 77 - 87

XGRm: A Web Server for Interpreting Mouse Summary-level Genomic Data.

Wang S. et al, (2024), J Mol Biol, 436

cross-disease, pleiotropy-driven approach for therapeutic target prioritization and evaluation.

Bao C. et al, (2024), Cell Rep Methods, 4

Priority index for critical Covid-19 identifies clinically actionable targets and drugs.

Zhang Z. et al, (2024), Commun Biol, 7

Priority index for asthma (PIA): In silico discovery of shared and distinct drug targets for adult- and childhood-onset disease.

Bao C. et al, (2023), Comput Biol Med, 162

Editorial: Translational phenomics and its applications in immunotherapy.

Fang H. et al, (2023), Front Immunol, 14

Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers.

Barton A. et al, (2022), Infect Immun, 90

Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis.

Vecellio M. et al, (2021), Arthritis Rheumatol, 73, 980 - 990

From the Genetics of Ankylosing Spondylitis to New Biology and Drug Target Discovery.

Nancy Z. et al, (2021), Front Immunol, 12

Identification of an Unconventional Subpeptidome Bound to the Behçet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1).

Chen L. et al, (2020), Mol Cell Proteomics, 19, 871 - 883

Identification of an Unconventional Subpeptidome Bound to the Behçet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1).

Chen L. et al, (2020), Mol Cell Proteomics, 19, 871 - 883

GM-CSF Primes Proinflammatory Monocyte Responses in Ankylosing Spondylitis.

Shi H. et al, (2020), Front Immunol, 11

From genome-wide association studies to rational drug target prioritisation in inflammatory arthritis.

Fang H. et al, (2020), Lancet Rheumatol, 2, e50 - e62

A genetics-led approach defines the drug target landscape of 30 immune-related traits.

Fang H. et al, (2019), Nat Genet, 51, 1082 - 1091

Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases.

Hammitzsch A. et al, (2018), Sci Rep, 8

Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators.

Lagou V. et al, (2018), Cell Rep, 25, 798 - 810.e6

Is Behçet's disease a 'class 1-opathy'? The role of HLA-B*51 in the pathogenesis of Behçet's disease.

Giza M. et al, (2018), Clin Exp Immunol, 191, 11 - 18

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis.

Al-Mossawi MH. et al, (2017), Nat Commun, 8

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.

Schwerd T. et al, (2017), J Exp Med, 214, 2547 - 2562

Deficiency of filaggrin regulates endogenous cysteine protease activity, leading to impaired skin barrier function.

Wang XW. et al, (2017), Clin Exp Dermatol, 42, 622 - 631

GTP cyclohydrolase accelerates tumor progression through interaction with angiopoietin-1 in stromal fibroblasts and activation of Tie2 on breast cancer cells

Chen L. et al, (2017), NCRI Cancer Conferences: Poster sessions

Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression.

Chen L. et al, (2017), Ann Rheum Dis, 76, 593 - 601

miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis.

Chen L. et al, (2017), Ann Rheum Dis, 76, 620 - 625

Related research themes

Inflammation biology

Tissue remodelling and repair

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