Translational medicine aims to expedite the discovery of new diagnostic tools and treatments by using a multi-disciplinary, highly collaborative, "bench-to-bedside" approach. The goal of Translational Medicine theme is to combine disciplines, resources, expertise, and techniques within these pillars to promote enhancements in prevention, diagnosis, and therapies. NDORMS co-ordinates a number of studies looking at the advances in understanding of the pathogenesis of inflammatory arthritis and the corresponding development of targeted therapies with proven efficacy in a number of these chronic inflammatory conditions, but numerous areas of unmet need remain. Most prominent among these are the low proportion of patients who do not attain sustained remission with currently available treatments and patients who consistently cite debilitating pain and fatigue as their major symptoms despite access to contemporary treatments. New, cost-effective interventions are required to address these issues.