Oppermann Group | Epigenetic Mechanisms in Musculoskeletal Disease
Epigenetics in bone and mesenchymal oncology
Epigenetic mechanisms in stem cell biology
Epigenetic mechanisms in inflammatory diseases
Target discovery in endometriosis + uterine fibroids
The research in our group focuses on target identification and validation in a spectrum of human diseases including benign and malignant soft tissue tumours or hematological malignancies affecting the skeleton such as multiple myeloma, and inflammatory conditions including endometriosis, cardiovascular disease, or autoimmune diseases.
The use of chemical, molecular and structural biology, combined with single-cell imaging and sequencing technologies provides a platform for us to understand human biology and is a major focus of the group. These approaches are currently applied to identify and validate epigenetic or metabolic mechanisms in stem cell biology, as well as chronic inflammatory, malignant and benign proliferative diseases.
In particular, our aim is to identify possible novel therapeutic intervention points in malignant such as bone and soft tissue cancers like sarcoma or in multiple myeloma, and in inflammatory or fibrotic conditions including arthritis and ankylosing spondylitis, cardiovascular disease, endometriosis or uterine fibroids. These goals are pursued in highly collaborative projects, such as the Oxford-Bayer Alliance in Women's Health and the Oxford Centre for Translational Myeloma Research.
Chemical tools such as selective and cell-active inhibitors are important in understanding biological systems. We pursue the development and characterisation of chemical tools for epigenetic biology within the Epigenetic Probe Project, a public-private partnership between the Structural Genomics Consortium (SGC) and several academic, private and patient organisations.
- Paul Brennan, Antony Tumber, Wyatt Yue & Chas Bountra (SGC, Oxford)
- Chris Schofield & Michael McDonough (Chemistry, Oxford)
- Chris Ponting & Andreas Heger (CGAT/DPAG, Oxford)
- Ulrich Guenther (Wellcome Trust centre for Biomolecular NMR, Birmingham)
- Bayer Healthcare
- Danica Fujimori & Brian Shoichet (UCSF)
Paul Wordsworth (NDORMS, Oxford)
- Nick La Thangue (Oncology, Oxford)
- Matt Brown & Emma Duncan (Diamantina Institute, Brisbane)
Tamer Onder (Koc University, Istanbul)