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Work in the Powrie lab is focused on understanding the interaction between the intestinal microbiota and the host immune system and how this mutualistic relationship breaks down in inflammatory bowel disease and cancer.

A multi-disciplinary approach is used to identify:

  • host cellular and molecular pathways that control the balance between homeostasis and inflammation and 
  • how microbial components control these responses. 

The lab performs basic and translational science and has strong links with Prof. Holm Uhlig and colleagues in the Translational Gastroenterology Unit in Oxford. In addition, we are closely aligned with the newly established Oxford Centre for Microbiome Studies




Intestinal Immune System

Intestinal Immune System

Colorectal Cancer


Selected publications

Related research themes