Powrie Group | Mucosal Immunology
Work in the Powrie lab is focused on understanding the interaction between the intestinal microbiota and the host immune system and how this mutualistic relationship breaks down in inflammatory bowel disease and cancer.
A multi-disciplinary approach is used to identify:
- host cellular and molecular pathways that control the balance between homeostasis and inflammation and
- how microbial components control these responses.
The lab performs basic and translational science and has strong links with Prof. Holm Uhlig and colleagues in the Translational Gastroenterology Unit in Oxford.
CURRENT AREAS OF INTEREST
Microbiome
Intestinal Immune System
Our team
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Alessandra Geremia
Academic Clinical Lecturer
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Claire Pearson
Laboratory Manager
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Emily Thornton
Postdoctoral Fellow
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Nicholas Ilott
Postdoctoral Research Scientist
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Samuel Bullers
Research Assistant
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Grigory Ryzhakov
Postdoctoral researcher
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Natasha Whibley
Postdoctoral Research Scientist
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Lilian Lam
EMBO Research Fellow
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Raphael Sanches Peres
EMBO Research Fellow
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Caroline Moussa
Research Technician
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Andrea Tucci
DPhil Student
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Carolina Arancibia
Research Fellow
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Matthias Friedrich
Postdoctoral Research Scientist
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Yisu Gu
Academic Clinical Training Fellow
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Daniel Johnston
Postdoctoral Researcher in Host-Microbial Interactions
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Elizabeth Mann
Postdoc Researcher in Gut T Cell Regulation
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Paula Colmenero
IAMC Scientific Project Manager
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Mathilde Pohin
Postdoctoral Researcher Scientist
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India Brough
Research Technician
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Alina Janney
DPhil Student
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Kevin Rue-Albrecht
Postdoctoral Researcher in Computational Genomics
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Matthew Jackson
Postdoctoral Researcher in Host-Microbial Interactions
PRINCIPAL INVESTIGATOR
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Fiona Powrie FRS
Professor of Musculoskeletal Sciences and Director of the Kennedy Institute
DPHIL IN INFECTION, IMMUNOLOGY AND TRANSLATIONAL MEDICINE
Professor Fiona Powrie is Director of the DPhil programme in Infection, Immunology and Translational Medicine, part of the Medical Sciences Doctoral Training Centre.
More information here.
Latest news
Kennedy Institute leads international consortium to investigate the link between gut bacteria and arthritis
Selected publications
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A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages.
Journal article
Danne C. et al, (2017), Cell host & microbe, 22, 733 - 745.e5
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Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.
Journal article
Hegazy AN. et al, (2017), Gastroenterology, 153, 1320 - 1337.e16
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Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.
Other
West NR. et al, (2017), Nature medicine, 23
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Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling.
Journal article
Ilott NE. et al, (2016), The ISME journal, 10, 2389 - 2404
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Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis.
Journal article
Griseri T. et al, (2015), Immunity, 43, 187 - 199
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The alarmin IL-33 promotes regulatory T-cell function in the intestine.
Journal article
Schiering C. et al, (2014), Nature, 513, 564 - 568
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Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.
Journal article
Kirchberger S. et al, (2013), The Journal of experimental medicine, 210, 917 - 931
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Intestinal homeostasis and its breakdown in inflammatory bowel disease.
Journal article
Maloy KJ. and Powrie F., (2011), Nature, 474, 298 - 306
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Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.
Journal article
Buonocore S. et al, (2010), Nature, 464, 1371 - 1375