Powrie Group | Mucosal Immunology
Work in the Powrie lab is focused on understanding the interaction between the intestinal microbiota and the host immune system and how this mutualistic relationship breaks down in inflammatory bowel disease and cancer.
A multi-disciplinary approach is used to identify:
- host cellular and molecular pathways that control the balance between homeostasis and inflammation and
- how microbial components control these responses.
The lab performs basic and translational science and has strong links with Prof. Holm Uhlig and colleagues in the Translational Gastroenterology Unit in Oxford. In addition, we are closely aligned with the newly established Oxford Centre for Microbiome Studies.
CURRENT AREAS OF INTEREST
Microbiome
Intestinal Immune System
Our team
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Alessandra Geremia
Academic Clinical Lecturer
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Claire Pearson
Laboratory Manager & OCMS Experimental Lead
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Emily Thornton
Postdoctoral Fellow
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Nicholas Ilott
Postdoctoral Research Scientist
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Samuel Bullers
Postdoctoral Research Assistant & OCMS Experimental Lead
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Natasha Whibley
Postdoctoral Research Scientist
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Lilian Lam
EMBO Research Fellow
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Raphael Sanches Peres
Postdoctoral Researcher
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Caroline Moussa
Research Technician
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Matthias Friedrich
Postdoctoral Research Scientist
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Daniel Johnston
Postdoctoral Researcher in Host-Microbial Interactions
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Elizabeth Mann
Postdoc Researcher in Colorectal Cancer
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Paula Colmenero
IAMC Scientific Project Manager
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Mathilde Pohin
Postdoctoral Researcher Scientist
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India Brough
DPhil Student
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Alina Janney
DPhil Student
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Matthew Jackson
Postdoctoral Researcher in Host-Microbial Interactions
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Dorothee Berthold
DPhil Student
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Rachel Feeney
Laboratory Technician
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Cornelia Heuberger
DPhil student
PRINCIPAL INVESTIGATOR
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Fiona Powrie FRS
Professor of Musculoskeletal Sciences and Director of the Kennedy Institute
Open Studentships
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Are metabolites generated by the microbiota key to a young immune system?
- Investigating the role of myeloid – stromal interaction in therapy refractory IBD patients
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Manipulating the microbiome to promote gut health Funded World Wide
- Physiological cross-talk between the liver and gut in healthy aging
Selected publications
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The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages.
Journal article
Schulthess J. et al, (2019), Immunity, 50, 432 - 445.e7
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Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.
Journal article
Ryzhakov G. et al, (2018), Nat commun, 9
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A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages.
Journal article
Danne C. et al, (2017), Cell host microbe, 22, 733 - 745.e5
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Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.
Journal article
Hegazy AN. et al, (2017), Gastroenterology, 153, 1320 - 1337.e16
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Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.
Other
West NR. et al, (2017), Nat med, 23
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Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling.
Journal article
Ilott NE. et al, (2016), Isme j, 10, 2389 - 2404
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The alarmin IL-33 promotes regulatory T-cell function in the intestine.
Journal article
Schiering C. et al, (2014), Nature, 513, 564 - 568
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Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.
Journal article
Kirchberger S. et al, (2013), J exp med, 210, 917 - 931
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Intestinal homeostasis and its breakdown in inflammatory bowel disease.
Journal article
Maloy KJ. and Powrie F., (2011), Nature, 474, 298 - 306
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Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.
Journal article
Buonocore S. et al, (2010), Nature, 464, 1371 - 1375