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There is mounting evidence implicating cytokines such as interleukin-1 in the local regulation of bone homeostasis. In this report we show that recombinant human interleukin-1 beta (rhIL-1 beta) influences several activities of osteoblast-like cells derived from human trabecular bone explants in vitro. rhIL-1 beta stimulated cellular proliferation and the synthesis of prostaglandin E2 and plasminogen activator activity in the cultured human osteoblast-like cells in a dose-dependent manner. However, the induction of osteocalcin synthesis and alkaline phosphatase activity in response to 1,25(OH)2D3, two characteristics of the osteoblast phenotype, were antagonized by rhIL-1 beta over a similar dose range. This study adds further support to the potential role of interleukin-1 in the physiological and pathological modulation of bone cell metabolism.

Original publication

DOI

10.1016/0006-291x(90)91932-i

Type

Journal article

Journal

Biochem biophys res commun

Publication Date

15/01/1990

Volume

166

Pages

208 - 216

Keywords

Alkaline Phosphatase, Bone and Bones, Calcitriol, Cell Division, Cells, Cultured, Dinoprostone, Dose-Response Relationship, Drug, Humans, Interleukin-1, Kinetics, Osteoblasts, Osteocalcin, Plasminogen Activators, Recombinant Proteins