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OCTRU runs trials across multiple areas of medicine. Within OCTRU there are five core therapeutic areas of expertise, although trials are also undertaken outside of these areas and groups.

Oncology Clinical Trials Office (OCTO)

Our current portfolio is divided into 3 categories: late phase, early phase and radiotherapy & imaging. Tumours types include; colorectal, oesophageal, melanoma, lung, breast, cervical, haematology, and bone sarcoma, in both adjuvant and advanced disease. The studies assess interventions including radiotherapy, drug combinations and novel imaging techniques.

Trauma and Emergency Care Group

We run a number of clinical trials in orthopaedic trauma and aim to inform best practice in the field, as well as the National Institute for Health and Care Excellence (NICE) guidelines. The Trauma and Emergency Care group is situated at the Kadoorie Critical Care Research Centre located at the John Radcliffe Hospital.

Rehabilitation Research in Oxford (RRIO)

The Centre for Rehabilitation Research in Oxford (RRIO) is a group within the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) at University of Oxford. We are leading research into how exercise and physiotherapy can be used to support the rehabilitation of patients with acute musculoskeletal injures such as a fracture or sprain, and patients with chronic conditions, such as rheumatoid arthritis or persistent back pain. We look at how structured physical activity can be offered as an effective method of rehabilitation for patients either alongside, or as an alternative to, standard medication.

Experimental Medicine and Rheumatology

Our focus is the use of experimental medicine techniques to elucidate the mechanism of action and potential clinical utility of novel therapeutic agents. The core of our work is in rheumatology but as the portfolio expands we are applying these approaches to other therapeutic area.

Surgical Intervention Trials Unit (SITU)

The Surgical Intervention Trials Unit (SITU) is a team of surgical investigators who are providing trial management support, and a training and development hub for surgical trialists within the UK.