Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Twenty-seven patients with severe open fractures were studied prospectively analysing infection and union as outcome measures. A standard treatment regime was applied. Seven patients were HIV positive, and 20 patients HIV negative. Wound infection and delayed union were more common in HIV positive patients. The difference in rate of infection was statistically significant (P = 0.020), while that in union did not quite reach significance (P = 0.059). The authors have developed an algorithm for treatment of these injuries in areas of high seroprevalence of HIV infection.

Original publication




Journal article



Publication Date





852 - 856


Adult, Anti-Bacterial Agents, Clinical Protocols, External Fixators, Female, Fracture Fixation, Fracture Healing, Fractures, Open, HIV Infections, Humans, Male, Middle Aged, Prospective Studies, Single-Blind Method, Surgical Wound Infection, Tibial Fractures, Treatment Outcome