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Ramanand et al. perform the first high-resolution 3D genome mapping via ChIA-PET to capture RNAPII-associated chromatin interactions in normal prostate epithelial and prostate cancer cells. They describe how genetics, epigenetics, and the 3D genome architecture are coordinated in the aberrant gene expression that drives prostate cancer development.

Original publication

DOI

10.1016/j.tig.2020.06.001

Type

Journal article

Journal

Trends genet

Publication Date

16/06/2020

Keywords

3D genome organization, chromatin architecture, prostate cancer