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The ability of LAK cells and/or IL-2 to affect the course of an established T cell response was examined in a delayed-type hypersensitivity (DTH) model. IL-2 greatly increased the magnitude of the response at 24 h, while LAK cells alone had no effect. The administration of LAK cells and IL-2 together also had no effect on the magnitude of the DTH response, demonstrating that LAK cells were able to remove the enhancement seen with IL-2 alone. The presence of LAK cells reduced the serum half-life of IL-2 significantly, but not to an extent able to account for the observed loss of IL-2 induced DTH enhancement. IL-2 administration influenced cell phenotypes in the spleen and draining lymph nodes (DLN), as well as increasing splenic weight; the additional presence of LAK cells markedly altered these effects of IL-2 in the spleen (but not the DLN). Taken together, these results suggest that LAK cells interact with activated T-cells within the immune system and modulate their function.

Original publication




Journal article


Clinical and experimental immunology

Publication Date





519 - 524


Department of Surgery, Western Infirmary, Glasgow, Scotland, UK.


Killer Cells, Lymphokine-Activated, T-Lymphocytes, Animals, Mice, Inbred BALB C, Mice, Dermatitis, Contact, Hypersensitivity, Delayed, Dinitrochlorobenzene, Cell Extracts, Interleukin-2, Immunotherapy, Antibody Formation, Immunity, Cellular, Phenotype, Female