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BACKGROUND: Coronary PET shows promise in the detection of high-risk atherosclerosis, but there remains a need to optimize imaging and reconstruction techniques. We investigated the impact of reconstruction parameters and cardiac motion-correction in 18F Sodium Fluoride (18F-NaF) PET. METHODS: Twenty-two patients underwent 18F-NaF PET within 22 days of an acute coronary syndrome. Optimal reconstruction parameters were determined in a subgroup of six patients. Motion-correction was performed on ECG-gated data of all patients with optimal reconstruction. Tracer uptake was quantified in culprit and reference lesions by computing signal-to-noise ratio (SNR) in diastolic, summed, and motion-corrected images. RESULTS: Reconstruction using 24 subsets, 4 iterations, point-spread-function modelling, time of flight, and 5-mm post-filtering provided the highest median SNR (31.5) compared to 4 iterations 0-mm (22.5), 8 iterations 0-mm (21.1), and 8 iterations 5-mm (25.6; all P 

Original publication




Journal article


J nucl cardiol

Publication Date





494 - 504


Atherosclerosis, Cardiac motion, Computed tomography, Positron emission tomography, Aged, Atherosclerosis, Diastole, Electrocardiography, Female, Fluorine Radioisotopes, Fluorodeoxyglucose F18, Heart, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Motion, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Radiopharmaceuticals, Reproducibility of Results, Signal-To-Noise Ratio