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Osteoporosis is a skeletal disorder characterized by reduced bone quantity and quality and an increased susceptibility to fracture, and seems to be one of many chronic conditions that might be influenced by events early in life. Specifically, there is growing evidence of an interaction between the genome and the environment in the expression of the disease.

Type

Journal article

Journal

Clinical obstetrics and gynecology

Publication Date

09/2013

Volume

56

Pages

549 - 555

Addresses

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, S016 6YD, UK. emd@mrc.soton.ac.uk

Keywords

Humans, Osteoporosis, Fetal Nutrition Disorders, Prenatal Exposure Delayed Effects, Epigenesis, Genetic, Gene Expression Regulation, Developmental, Pregnancy, Female, Male, Fractures, Bone, Maternal Nutritional Physiological Phenomena, Prenatal Nutritional Physiological Phenomena, Gene-Environment Interaction