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Osteoporosis is a skeletal disorder characterized by reduced bone quantity and quality and an increased susceptibility to fracture, and seems to be one of many chronic conditions that might be influenced by events early in life. Specifically, there is growing evidence of an interaction between the genome and the environment in the expression of the disease.


Journal article


Clinical obstetrics and gynecology

Publication Date





549 - 555


MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, S016 6YD, UK.


Humans, Osteoporosis, Fetal Nutrition Disorders, Prenatal Exposure Delayed Effects, Epigenesis, Genetic, Gene Expression Regulation, Developmental, Pregnancy, Female, Male, Fractures, Bone, Maternal Nutritional Physiological Phenomena, Prenatal Nutritional Physiological Phenomena, Gene-Environment Interaction