Can depth of invasion of pT1 carcinoma of the oral tongue predict occult metastases in the neck? A retrospective study.
Abu-Serriah M., Shah KA., Rajamanohara R., Fasanmade A., Graystone J., Gerry S., Bond S.
The depth of invasion is considered to be a predictor of occult metastases in the neck in patients with squamous cell carcinoma (SCC), but investigators do not agree about the depth at which the risk rises dramatically. As the association between depth of invasion of pT1 SCC of the oral tongue and occult metastases in the neck remains unknown, we collected data on patients with the disease and recorded the depth and pattern of invasion, neurovascular invasion, and presence of occult metastases. When all other factors were constant, the odds ratio for each millimetre increase in depth and risk of occult metastases was 1.09 (95% CI: 0.95 to 1.25, p=0.23), which was not significant. Depth of invasion is not accurate and cannot be used as predictor of occult metastases in the neck in patients with pT1 SCC of the tongue.