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Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.

Original publication




Journal article


J acquir immune defic syndr

Publication Date





314 - 318


Absorptiometry, Photon, Adult, Anti-HIV Agents, Bone Density, Cross-Sectional Studies, Female, Femur Neck, HIV Infections, Humans, Lumbar Vertebrae, Male, Middle Aged, Osteoporosis, Risk Assessment, Spain